Promethazine administered to your Expecting female within two months of shipping may inhibit platelet aggregation in the new child.
Impaired secretion from sweat glands adhering to poisonous doses of medication with anticholinergic Unwanted side effects may well predispose to hyperthermia.
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Notify clients that a house teaspoon is just not an precise measuring system and this sort of use could lead to overdosage and severe adverse reactions [see OVERDOSAGE (10)]. For prescriptions exactly where a measuring device will not be furnished, a pharmacist can provide an suitable calibrated measuring gadget and can provide Directions for measuring the correct dose.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric people below 6 decades of age.
There is no basic settlement about particular pharmacological treatment regimens for uncomplicated NMS.
Anticholinergics – Concomitant utilization of other agents with anticholinergic properties should be undertaken with warning.
Codeine is probably the By natural means occurring phenanthrene alkaloids of opium derived within the opium poppy; it is classed pharmacologically as being a narcotic read more analgesic.
The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients a lot less than six several years of age, mainly because The mixture may possibly lead to deadly respiratory depression Within this age population.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients fewer than six years of age. Concomitant administration of promethazine products with other respiratory depressants has an association with respiratory depression, and at times Loss of life, in pediatric sufferers. The association does indirectly relate to individualized fat-dependent dosing, which might normally permit Protected administration.
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Promethazine is perfectly absorbed from the gastrointestinal tract. Scientific consequences are evident within twenty minutes soon after oral administration and usually final four to 6 hrs, Though they may persist so long as 12 several hours.
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Postmarketing circumstances of respiratory depression, which includes fatalities have already been documented with use of promethazine in pediatric patients.